A new role for an old immune cell may lead to novel therapies for infection and cancer


By sciencedaily.com

A new study has identified a previously undescribed role for a type of unconventional T cell with the potential to be used in the development of new therapies for infection and cancer.

The study, published today in Nature Communications, shows that Gamma Delta T cells are able to generate immunological memory against previous infections and cancerous targets.

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The results challenge the textbook description of Gamma Delta T cells as 'natural born killers' with an innate ability to recognise and destroy abnormal cells.

Lead author of the study, Professor Ben Willcox from the Institute of Immunology and Immunotherapy at the University of Birmingham, explains the key findings: "Instead of being 'natural born killers', we found these cells are actually quite smart. They adapt to and remember what they have encountered in life, which may include infections and pre-cancerous cells.

"This phenomenon of 'immunological memory' is what current vaccines exploit, but because Gamma Delta T cells recognise their targets in a different way, they present novel routes to generate vaccines, and also cell therapy approaches against infection and cancer."

In order to harness these "adaptive" abilities of Gamma Delta T cells, work is now required to identify the mechanism by which they recognise abnormal cells.

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"We are working with other partners to understand exactly how these cells recognise signs of abnormality in infection and cancer, focussing on human cohorts. This knowledge will be crucial to help us build on the current study and explore how to develop new cell therapies and vaccines that exploit Gamma Delta T cells," adds Professor Willcox.

Source: https://www.sciencedaily.com/releases/2017/03/170301130506.htm

Thursday, May 7, 2026

Pioglitazone: The Generic Form Of Actos Explained

Pioglitazone is the generic name of the medication sold under the brand name Actos. Generic medications contain the same active ingredient at the same dose and strength as their brand name counterparts and must meet the same FDA standards for quality, purity, and bioequivalence. The development and approval of generic drugs play an important role in making effective treatments more accessible and affordable for patients. Diabetes management involves controlling blood sugar levels to prevent the long-term complications of the disease, which include heart disease, stroke, kidney failure, blindness, and peripheral neuropathy. A combination of lifestyle changes and medications is typically needed. Weight loss, regular physical activity, and dietary modification can significantly improve insulin sensitivity and blood glucose control, particularly in the early stages of the disease. As the condition progresses, most people require one or more antidiabetic medications. The pharmacological action of pioglitazone is the basis for its use in treating conditions within the category of diabetes care. Understanding the mechanism by which the active compound produces its therapeutic effects helps patients appreciate why the medication needs to be taken consistently and at the correct dose to achieve the best results. Switching between brand name and generic versions of a medication is generally considered safe when the products are bioequivalent, but patients should inform their doctor if they notice any differences in effect after a formulary change. Some patients with conditions requiring precise drug levels in the blood may be monitored more closely during transitions. For most patients, however, approved generics provide equivalent therapeutic benefit to the brand name product. The diabetes care section on diabetes care covers both brand name and generic treatment options, giving patients a complete picture of what is available. Cost, insurance coverage, and pharmacy availability are practical factors to discuss with a pharmacist when filling a prescription for pioglitazone.

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